Deebo Samuel caught six passes for 115 yards, including a long catch-and-run touchdown, and Talanoa Hufanga scored on an interception return to help the San Francisco 49ers notch a 24-9 victory over the Los Angeles Rams on Monday night at Santa Clara, Calif.

Jimmy Garoppolo completed 16 of 27 passes for 239 yards and one touchdown and Jeff Wilson Jr. rushed for 74 yards and one score as San Francisco (2-2) won its seventh consecutive regular-season game over the Rams (2-2). Of course, Los Angeles won the biggest recent meeting, beating the 49ers in last season's NFC Championship Game en route to winning the Super Bowl.

Matthew Stafford connected on 32 of 48 passes for 254 yards with one interception and one lost fumble for the Rams. Cooper Kupp caught a career-best 14 passes for 122 yards, Tyler Higbee made 10 catches for 73 yards and Matt Gay kicked three field goals for Los Angeles.

Nick Bosa and Samson Ebukam each had two of San Francisco's seven sacks. Bosa leads the NFL with six. Ebukam forced Stafford to fumble on one of his sacks.

Hufanga made his big play when Stafford was trying to rally the Rams from an eight-point, fourth-quarter deficit. Hufanga, who anticipated that Stafford would throw a quick pass to Kupp, jumped the route, made the interception and returned it 52 yards for a touchdown to give San Francisco a 24-9 advantage with 6:27 to play.

The 49ers outgained Los Angeles 327 yards to 257. The Rams didn't have a single 20-yard offensive play.

The Rams controlled the ball for the first 8:12 of the contest, but their drive stalled and they settled for Gay's 39-yard field goal.

San Francisco then struck as Wilson exploded for a 32-yard touchdown run with 2:46 left in the opening quarter.

Gay booted a 29-yard field goal with 6:22 left in the half before Samuel produced his dynamic 57-yard scoring reception. He caught the ball at his own 49-yard line and later easily eluded Jalen Ramsey's tackle attempt at the Rams' 22 en route to giving the 49ers a 14-6 advantage.

Los Angeles had a 16-play, 75-yard drive in the third quarter but couldn't finish it off. The excursion took 7:43 and ended with Gay's 26-yard field goal.

Robbie Gould kicked a 25-yard field goal on the second play of the fourth quarter to restore San Francisco's eight-point lead.